D\u00fcnyan\u0131n d\u00f6rt bir yan\u0131nda etkili olan yeni tip corona vir\u00fcs pandemisi nedeniyle \u00f6l\u00fc say\u0131s\u0131 1 milyonu a\u015farken, k\u00fcresel a\u015f\u0131 rekabeti son h\u0131zda devam ediyor. A\u015f\u0131 yar\u0131\u015f\u0131na son kat\u0131lanlardan biri olan ABD\u2019li Codagenix adl\u0131 firma, di\u011ferlerinden farkl\u0131 bir yakla\u015f\u0131m benimseyerek corona vir\u00fcs\u00fcn canl\u0131 olarak kullan\u0131ld\u0131\u011f\u0131 bir a\u015f\u0131 geli\u015ftirdi. insanlar\u0131 enfekte ederek ba\u011f\u0131\u015f\u0131kl\u0131k kazand\u0131rmay\u0131 hedefleyen a\u015f\u0131n\u0131n y\u0131l sonunda insan denemelerine ba\u015flanmas\u0131 bekleniyor. S\u00f6z konusu a\u015f\u0131n\u0131n MMR a\u015f\u0131s\u0131na benzer bir \u015feklide canl\u0131 mikrop ile uygulanaca\u011f\u0131, yani zay\u0131flat\u0131lm\u0131\u015f ama yine de bula\u015f\u0131c\u0131 olan geneti\u011fi de\u011fi\u015ftirilmi\u015f bir corona vir\u00fcs formunu i\u00e7erece\u011fi belirtildi.<\/p>\n\n\n\n
ABD\u2019de New York merkezli Codagenix adl\u0131 ila\u00e7 \u015firketi, geleneksel bir a\u015f\u0131ya k\u0131yasla daha g\u00fc\u00e7l\u00fc bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi tetiklemek i\u00e7in yeni tip corona vir\u00fcs\u00fcn canl\u0131 ancak zay\u0131flat\u0131lm\u0131\u015f versiyonuyla bir a\u015f\u0131 geli\u015ftirdi.<\/p>\n\n\n\n
\u015eirketten yap\u0131lan a\u00e7\u0131klamada a\u015f\u0131n\u0131n hayvan deneylerinin ba\u015far\u0131l\u0131 oldu\u011fu ve y\u0131l sonunda \u0130ngiltere\u2019nin ba\u015fkenti Londra\u2019da\u00a0 insan deneylerine ba\u015flanaca\u011f\u0131 a\u00e7\u0131kland\u0131.<\/p>\n\n\n\n
\u015eu anda d\u00fcnyada 200’den fazla corona vir\u00fcs a\u015f\u0131s\u0131 geli\u015ftiriliyor ve bir d\u00fczineden fazlas\u0131 insan deneyleri yap\u0131yor. S\u00f6z konusu a\u015f\u0131lar\u0131n hepsi Covid-19\u2019la sava\u015fmak i\u00e7in farkl\u0131 yakla\u015f\u0131mlar benimsiyor. Bu a\u015f\u0131lar, adenovir\u00fcs 5, k\u0131zam\u0131k ya da \u00a0grip vir\u00fcslerinin DNA\u2019s\u0131 ya da RNA\u2019s\u0131n\u0131n geneti\u011finin de\u011fi\u015ftirilmesi tekni\u011fina dayan\u0131yor ancak hi\u00e7biri do\u011frudan yeni tip corona vir\u00fcs\u00fc i\u00e7ermiyor.\u00a0<\/p>\n\n\n\n
\u00a0Bununla birlikte, bu yakla\u015f\u0131mlar\u0131n her birinin yan etkiler, d\u00fc\u015f\u00fck etkinlik, zay\u0131f ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi, s\u0131n\u0131rl\u0131 \u00fcretim gibi dezavantajlar\u0131 da bulunuyor. Bu nedenle, s\u00f6z konusu sorunlar\u0131n baz\u0131lar\u0131n\u0131n \u00fcstesinden gelmek i\u00e7in Codagenix, uygulamas\u0131 \u00e7ok daha kolay ve daha h\u0131zl\u0131 olan bir yakla\u015f\u0131ma gitmeye karar verdi\u011fini \u00f6ne s\u00fcrd\u00fc.\u00a0<\/p>\n\n\n\n
Ger\u00e7ek yeni tip corona vir\u00fcs\u00fcn zay\u0131flat\u0131lm\u0131\u015f versiyonunu i\u00e7eren CDX-005 adl\u0131 a\u015f\u0131n\u0131n burundan uygulanaca\u011f\u0131 ve ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini g\u00fcvenli bir \u015fekilde tetikleyebilece\u011fi ifade edildi.<\/p>\n\n\n\n
Influenza, Zika, rhinovir\u00fcs ya da yeni tip corona vir\u00fcs olsun, her vir\u00fcs, genomunu \u00e7evirmek ve proteinlerini sentezlemek i\u00e7in konak\u00e7\u0131 h\u00fccrenin ribozom mekanizmas\u0131n\u0131 kullan\u0131yor.\u00a0<\/p>\n\n\n\n
Codagenix bilgisayar algoritmas\u0131 ile \u00a0viral genlerin kodonlar\u0131n\u0131 yeniden kodlayarak de-optimize ediyor. B\u00f6ylelikle vir\u00fcs konak\u00e7\u0131 g\u00fccrenin \u00a0ribozomu taraf\u0131ndan daha yava\u015f okunan bir hale getiriliyor. \u00a0K\u0131sacas\u0131, “optimize edilmemi\u015f” genler, normal vir\u00fcsteki ile ayn\u0131 protein dizilerini kodluyor, ancak vir\u00fcs v\u00fccutta bu \u015fekilde daha hareket ediyor ve \u00e7o\u011falma imkan\u0131 bulam\u0131yor.<\/p>\n\n\n\n
Corona vir\u00fcs tipik olarak 24 saat i\u00e7inde bir h\u00fccrede 100 milyon kez \u00e7o\u011falabilirken, “optimize edilmemi\u015f” versiyonuyla bin kat daha az art\u0131yor.<\/p>\n\n\n\n
Codagenix Ba\u015fkan\u0131 Robert Coleman, Technology Review\u2019e yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, “V\u00fccutta bin kat daha az \u00e7o\u011falabilir, bu da ba\u011f\u0131\u015f\u0131kl\u0131k sistemine yan\u0131t vermesi i\u00e7in daha fazla zaman tan\u0131r. Ortaya \u00e7\u0131kan bu vir\u00fcs sadece daha az patojenik olmakla kalmaz, ayn\u0131 zamanda geleneksel a\u015f\u0131lardan \u00e7ok daha g\u00fc\u00e7l\u00fc bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini tetikler \u00e7\u00fcnk\u00fc ger\u00e7ek vir\u00fcs\u00fcn t\u00fcm antijenleri i\u00e7inde mevcuttur.B\u00f6ylece, canl\u0131 bir t\u00fcr kullanan a\u015f\u0131 ile v\u00fccut, vir\u00fcs\u00fcn sadece bir k\u0131sm\u0131yla de\u011fil, t\u00fcm vir\u00fcsle kar\u015f\u0131la\u015f\u0131r. V\u00fccut daha sonra sadece antikorlar \u00fcreterek de\u011fil, ayn\u0131 zamanda T h\u00fccreleri ve burun ge\u00e7i\u015flerinde ba\u011f\u0131\u015f\u0131kl\u0131k \u00fcreterek tepki verir, b\u00f6ylece genel korumay\u0131 geni\u015fletir\u201d ifadelerini kulland\u0131.<\/p>\n\n\n\n
\u00d6te yandan, canl\u0131 a\u015f\u0131 tekni\u011fi, su \u00e7i\u00e7e\u011fi, \u00e7ocuk felci, k\u0131zam\u0131k ve sar\u0131 hummaya kar\u015f\u0131 geli\u015ftirilen a\u015f\u0131larda on y\u0131llard\u0131r kullan\u0131l\u0131yor.<\/p>\n\n\n\n
Bununla birlikte, t\u00fcm avantajlar\u0131na ra\u011fmen, piyasada nispeten az say\u0131da canl\u0131 vir\u00fcs bazl\u0131 a\u015f\u0131 bulunuyor. Coleman, New York Times’a verdi\u011fi bir di\u011fer deme\u00e7te, \u00a0\u201cKodu s\u00fcrekli de\u011fi\u015ftirmeniz gerekiyor. Mutasyonlar\u0131n nas\u0131l davranaca\u011f\u0131n\u0131 asla bilemezsiniz. M\u00fcmk\u00fcn olan en iyi kodu bulmak i\u00e7in bu y\u00fczden yapay zeka kullan\u0131yoruz\u201d dedi.<\/p>\n\n\n\n
Kaynak – NTV Haber<\/p>\n","protected":false},"excerpt":{"rendered":"
D\u00fcnyan\u0131n d\u00f6rt bir yan\u0131nda etkili olan yeni tip corona vir\u00fcs pandemisi nedeniyle \u00f6l\u00fc say\u0131s\u0131 1 milyonu a\u015farken, k\u00fcresel a\u015f\u0131 rekabeti son h\u0131zda devam ediyor. A\u015f\u0131 yar\u0131\u015f\u0131na son kat\u0131lanlardan biri olan ABD\u2019li Codagenix adl\u0131 firma, di\u011ferlerinden farkl\u0131 bir yakla\u015f\u0131m benimseyerek corona vir\u00fcs\u00fcn canl\u0131 olarak kullan\u0131ld\u0131\u011f\u0131 bir a\u015f\u0131 geli\u015ftirdi. insanlar\u0131 enfekte ederek ba\u011f\u0131\u015f\u0131kl\u0131k kazand\u0131rmay\u0131 hedefleyen a\u015f\u0131n\u0131n y\u0131l …<\/p>\n","protected":false},"author":2,"featured_media":1794,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[23],"tags":[],"_links":{"self":[{"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/1792"}],"collection":[{"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1792"}],"version-history":[{"count":1,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/1792\/revisions"}],"predecessor-version":[{"id":1793,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/1792\/revisions\/1793"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=\/wp\/v2\/media\/1794"}],"wp:attachment":[{"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1792"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1792"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/karagumruk.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}